Winners: Queen's Park

Runners-up: Dumbarton

Holders from previous season: Queen's Park


First round
Walkover5th Kirkcudbrightshire Rifle Volunteers Cree RoversScratched
18 September 188017th Renfrew Rifle Volunteers6-1Wellington Park
18 September 1880Abercorn7-1Barrhead
18 September 1880Airdrie3-0Bellshill
WalkoverAirdriehill Airdrie BluebellScratched
18 September 1880Alexandra Athletic4-1Kelvinbank
WalkoverArbroath Vale of TeithScratched
4 September 1880Arthurlie2-0Johnstone
11 September 1880Athole1-1Whitefield
18 September 1880Auchinleck Boswell1-7Cumnock
11 September 1880Ayr2-0Catrine
11 September 1880Beith4-1Irvine
18 September 1880Caledonian1-2Clyde
WalkoverCambuslang Upper ClydesdaleScratched
18 September 1880Campsie Central2-0Bridge of Allan
18 September 1880Cartside6-2Kennishead
WalkoverCartvale LevernScratched
WalkoverCity 19th Lanark Rifle VolunteersScratched
4 September 1880Clarkston1-0Plains Bluebell
18 September 1880Coupar Angus4-1Strathmore
4 September 1880Cowlairs4-3Petershill
11 September 1880Dumbarton7-0Helensburgh Victoria
18 September 1880Dunfermline5-3Hanover
WalkoverDunkeld St Clement'sScratched
11 September 1880Excelsior3-0Drumpelier
WalkoverFalkirk Campsie AthleticScratched
WalkoverHamilton Academical StonelawScratched
WalkoverHarmonic AilsaScratched
11 September 1880Heart of Midlothian3-1Brunswick
WalkoverHurlford Ayr ThistleScratched
11 September 1880Jamestown6-0Alcutha
18 September 1890Jordanhill1-0Windsor
18 September 1880Kilbirnie3-0Lanemark
WalkoverKilmarnock Stewarton CunninghameScratched
WalkoverKilmarnock Athletic GirvanScratched
11 September 1880Kilmarnock Portland8-0Coylton Coila
18 September 1880King's Park1-0Strathblane
11 September 1880Lennox1-2HelensburghMatch declared void
WalkoverMauchline DeanScratched
30 September 1880Maybole3-1Rankinston Volunteers
4 September 1880Milton of Campsie2-1Grasshoppers
18 September 1880Morton3-2Glenkilloch
WalkoverNetherlee OakfieldScratched
11 September 1880Northern3-13rd Lanark Rifle Volunteers
11 September 1880Oxford6-0Maxwell
18 September 1880Pilgrims4-2Lancefield
WalkoverPartick Thistle DennistounScratched
4 September 1880Pollok5-0Johnstone Rovers
11 September 1880Pollokshields Athletic0-4Partick
WalkoverPossilpark High SchoolScratched
11 September 1880Queen's Park7-0John Elder
11 September 1880Rangers4-1Govan
WalkoverRenton Kilmarnock ThistleScratched
11 September 1880Rob Roy2-1Dundee Our Boys
WalkoverShawlands Athletic ClydesdaleScratched
11 September 1880Shotts4-0Lanark
11 September 1880South Western7-0Ingram
4 September 1880St Mirren3-0Johnstone Athletic
18 September 1880Star of Leven3-2Kirkintilloch Athletic
11 September 1880Stranraer3-0Queen of the South Wanderers
11 September 1880Thistle5-0Tolcross Athletic
18 September 1880Thornliebank3-0Renfrew
11 September 1880Uddingston2-2Royal Albert
WalkoverYoker Renfrew RamblersScratched
ByeEdinburgh University
ByeGlasgow University
ByePossil Bluebell
ByeVale of Leven
25 September 1880Helensburgh8-1Lennox
18 September 1880Royal Albert5-0Uddingston
25 September 1880Whitefield1-2Athole
Second round
9 October 18805th Kirkcudbrightshire Rifle Volunteers4-3Stranraer
2 October 1880Abercorn4-2Morton
2 October 1880Airdrie3-2Excelsior
2 October 1880Alexandra Athletic1-0Athole
2 October 1880Arthurlie1-1Cartvale
9 October 1880Cambuslang3-1Hamilton Academical
2 October 1880Campsie Central5-5Milton of Campsie
2 October 1880Clarkston2-1Airdriehill
2 October 1880Coupar Angus1-2Arbroath
9 October 1880Cowlairs4-3Oxford
2 October 1880Dumbarton2-1Jamestown
2 October 1880Falkirk2-1King's Park
2 October 1880Glengowan1-1Thistle
2 October 1880Harmonic1-1Clyde
2 October 1880Helensburgh5-1Star of Leven
9 October 1880Hibernian3-1Dunfermline
2 October 1880Hurlford2-1Cumnock
2 October 1880Kilbirnie3-0Kilmarnock ThistleMatch declared void
9 October 1880Kilmarnock6-3Ayr
2 October 1880Kilmarnock Portland0-1Beith
9 October 1880Mauchline6-1Maybole
2 October 1880Netherlee0-2Yoker
9 October 1880Partick Thistle1-0Jordanhill
9 October 1880Pilgrims7-0City
2 October 1880Queen's Park5-0Possilpark
2 October 1880Rangers1-0Northern
9 October 1880Renton0-1Vale of Leven
2 October 1880Rob Roy4-0Dunkeld
2 October 1880Royal Albert1-0Shotts
WalkoverShawlands Athletic Possil BluebellScratched
9 October 1880South Western2-0Partick
2 October 1880St Mirren3-217th Renfrew Rifle Volunteers
2 October 1880Thornliebank0-3Pollok
ByeEdinburgh University
ByeGlasgow University
ByeHeart of Midlothian
9 October 1880Cartvale1-2Arthurlie
9 October 1880Clyde1-0Harmonic
16 October 1880Kilbirnie2-1Kilmarnock Thistle
9 October 1880Milton of Campsie1-3Campsie Central
9 October 1880Thistle6-1Glengowan
Third round
23 October 1880Abercorn1-4St Mirren
6 November 1880Alexandra Athletic1-2Cowlairs
6 November 1880Arbroath2-1Rob Roy
23 October 1880Arthurlie2-0Pollok
23 October 1880Beith17-25th Kirkcudbrightshire Rifle Volunteers
30 October 1880Campsie Central6-1Lenzie
30 October 1880Cartside4-3Yoker
23 October 1880Clyde3-0Shawlands Athletic
23 October 1880Dumbarton7-1Falkirk
23 October 1880Heart of Midlothian5-3Hibernian
23 October 1880Helensburgh1-4Vale of Leven
23 October 1880Kilbirnie0-2Hurlford
6 November 1880Mauchline3-3Kilmarnock
23 October 1880Queen's Park8-1Pilgrims
23 October 1880Rangers3-0Partick Thistle
23 October 1880Royal Albert0-5Cambuslang
WalkoverThistle AirdrieScratched
ByeEdinburgh University
ByeGlasgow University
ByeSouth Western
13 November 1880Kilmarnock0-3Mauchline
Fourth round
13 November 1880Arthurlie4-3South WesternMatch declared void
20 November 1880Cartside1-3Hurlford
13 November 1880Dumbarton9-0Glasgow University
13 November 1880Edinburgh University0-1Campsie Central
13 November 1880Heart of Midlothian3-0Cambuslang
WalkoverMauchline ClarkstonScratched
13 November 1880Queen's Park11-2Beith
13 November 1880Rangers11-0Clyde
13 November 1880St Mirren1-0Cowlairs
WalkoverVale of Leven ArbroathScratched
27 November 1880Arthurlie1-1South WesternSouth Western disqualified
Fifth round
11 December 1880Arthurlie4-0Heart of Midlothian
18 December 1880Hurlford0-3Rangers
11 December 1880Mauchline0-2Queen's Park
4 December 1880St Mirren1-5Dumbarton
4 December 1880Vale of Leven7-1Thistle
ByeCampsie Central
25 December 1880Arthurlie0-2Vale of Leven
25 December 1880Campsie Central1-10Queen's Park
25 December 1880Rangers1-3Dumbarton
5 February 1881Vale of Leven0-2Dumbarton
ByeQueen's Park
26 March 1881Queen's Park2-1DumbartonPlayed at Kinning Park, Glasgow
15,000 Match declared void after Dumbarton protested about spectators encroching on the pitch and a replay was ordered. Queen's Park also threatened to withdraw from the Scottish Football Association. The gates had to be closed during the replay.    
9 April 1881Queen's Park3-1DumbartonPlayed at Kinning Park, Glasgow
10,000Smith (3) Meikleham